Requirements
Please refer to the macOS Compatibility Chart for hardware and macOS version requirements.
Installation
Step 1
Disable "Open using Rosetta" option in the Info panel of the Cinema4D application.

Step 2
Create the plugins folder inside the C4D R2X directory in lower case. The installation path for macOS is HD/Applications/Maxon Cinema 4D R2X/plugins/OctaneRender (You have to create the plugins folder in lower case!)
Step 3
Copy the uncompressed OctaneRender folder into the plugins folder. Next, delete the c4doctane-R2X.xdlib files not associated with your R2X version, leaving only the c4doctane-R2X.xdlib file matching your Cinema 4D version. For example, if you are using C4D R2025, you would keep just the c4dOctane-R2025.xlib file.